Hypertension is a growing problem in the United States, exerting a great toll on the national health and economy. The Rattus norvegicus Spontaneously Hypertensive Rat (SHR) strain has been the preferred physiological model for the study of essential hypertension for decades. Both humans and rats show a pattern of Y chromosome linked hypertension, consistent with a conserved Y chromosome hypertensive locus in mammals. The Y chromosome gene, Sry has long been known for testis determination in mammals, but transcription in adult male tissues and reported effects on regulatory pathways makes Sry a candidate gene for the Y chromosome hypertensive locus. While most mammals have a single Sry locus on the Y chromosome, several rodent species have been shown to have multiple loci. Previously, six divergent loci of Sry had been identified in The University of Akron’s SHR (SHR/Akr) strain, with full coding region and conserved reading frame, but differing by SNPs and insertions/deletions. Here, sequence data of Sry loci was expanded to include more flanking sequence in SHR/Akr and three additional rat strains, with the intent of identifying hypertensive sequence [...]
Farkas, J. A.: Sequence Analysis of Sry in four Strains of Rattus norvegicus
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